Traditional and systems biology based drug discovery for the rare tumor syndrome neurofibromatosis type 2.
Neurofibromatosis 2 (NF2) is a rare tumor suppressor syndrome that manifests with multiple schwannomas and meningiomas.There are no effective drug therapies for these benign tumors and conventional therapies have limited efficacy.Various model systems have been created and several drug targets have been implicated in NF2-driven tumorigenesis based